CasNo： 62802-42-0
Molecular Formula： C4H2ClFN2
Appearance： Colorless to light yellow liquid
|
Preparation |
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine. |
InChI:InChI=1/C6H3ClFNO2/c7-5-4(8)3(6(10)11)1-2-9-5/h1-2H,(H,10,11)
The present invention provides imidazotr...
Two series of N-hydroxyformamide inhibit...
Disclosed are compounds active against s...
Aryl sulfonamide and sulfonyl compounds ...
2,4-dichloro-5-fluoropyrimidine
2-chloro-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
|
With
acetic acid; zinc;
In
tetrahydrofuran;
|
74% |
|
With
acetic acid; zinc;
In
tetrahydrofuran;
at 70 ℃;
for 6h;
Heating / reflux;
|
50% |
|
With
ammonium hydroxide; ammonium chloride; zinc;
In
benzene;
for 30h;
|
40% |
|
With
ammonium hydroxide; sodium chloride; zinc;
In
benzene;
for 6.5h;
Heating;
|
|
|
With
acetic acid; zinc;
In
tetrahydrofuran;
for 5h;
Heating;
|
|
|
With
acetic acid; zinc;
In
tetrahydrofuran;
for 10h;
Heating / reflux;
|
|
|
2,4-dichloro-5-fluoropyrimidine;
With
zinc;
In
tetrahydrofuran;
at 20 - 70 ℃;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
at 70 ℃;
for 6h;
Inert atmosphere;
|
|
|
With
acetic acid;
In
tetrahydrofuran;
|
|
|
With
acetic acid;
In
tetrahydrofuran; hexane;
|
2,4,6-trichloro-5-fluoropyrimidine
2-chloro-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
|
With
hydrogen; triethylamine;
palladium on activated charcoal;
In
ethyl acetate;
at 50 ℃;
under 3000.2 Torr;
|
78% |
2,4-dichloro-5-fluoropyrimidine
2,4,6-trichloro-5-fluoropyrimidine
5-fluoro-2-(piperazin-1-yl)-pyrimidine
4-{[1-(5-fluoro-2-pyrimidinyl)-4-piperidinyl]oxy}-1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indole
5-fluoro-2-[(3R)-3-methylpiperazin-1-yl]pyrimidine
4-(5-fluoro-pyrimidin-2-yl)-benzaldehyde
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