Pharmaceutical

5451-09-2

  • Product Name：5-Aminolevulinic acid hydrochloride
  • Molecular Formula：C5H10ClNO3
  • Specifications：99%
  • Molecular Weight：167.592
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Product Details;

CasNo： 5451-09-2

Molecular Formula： C5H10ClNO3

Appearance： white to pale yellow crystals

5-Aminolevulinic acid hydrochloride Good Supplier In Bulk Supply High Purity 5451-09-2

  • Molecular Formula:C5H10ClNO3
  • Molecular Weight:167.592
  • Appearance/Colour:white to pale yellow crystals 
  • Vapor Pressure:0.000303mmHg at 25°C 
  • Melting Point:156-158 °C 
  • Boiling Point:298.4 °C at 760 mmHg 
  • Flash Point:134.3 °C 
  • PSA：80.39000 
  • LogP:0.71540 

5-Aminolevulinic acid hydrochloride(Cas 5451-09-2) Usage

Biochem/physiol Actions

5-Aminolevulinic acid (5-ALA) is an intermediate in heme biosynthesis and is useful in cancer treatment. It is a non-protein amino acid. 5-ALA also has applications in the field of agriculture. It is being studied as an inducing reagent for protoporphyrin IX (PPIX) dependent fluorescence diagnosis of metastatic lymph nodes. 5-ALA is used for photodynamic therapy of diseases, such as Paget′s disease and HPV infection-associated cervical condylomata acuminata.

Purification Methods

Dry ALA-HCl in a vacuum desiccator over P2O5 overnight, then crystallise it by dissolving it in cold EtOH and adding dry Et2O. Also crystallis

Definition

ChEBI: A hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderat ly thick actinic keratosis of the face or scalp.

InChI:InChI=1/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H

5451-09-2 Relevant articles

Convenient syntheses of δ-aminolevulinic acid

Nudelman, Ayelet,Nudelman, Abraham

, p. 568 - 570 (1999)

Two convenient procedures for the synthe...

Synthesis of the natural herbicide δ-aminolevulinic acid from cellulose-derived 5-(chloromethyl)furfural

Mascal, Mark,Dutta, Saikat

, p. 40 - 41 (2011)

Cellulose-derived 5-(chloromethyl)furfur...

A convenient method for introducing oxo group into the β-position of cyclic amines and its application to synthesis of δ-aminolevulinic acid

Matsumura,Takeshima,Okita

, p. 304 - 306 (1994)

Oxo group could be introduced into the β...

Synthesis method of 5-aminolevulinic acid hydrochloride

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Paragraph 0017; 0038; 0040-0041; 0043-0044; 0046-0047; ..., (2022/04/03)

The invention relates to a synthesis met...

Preparation method 5 - ALA intermediate 5 - bromoolevulinic acid ester

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Paragraph 0034; 0053; 0057, (2021/09/22)

The invention relates to a preparation m...

Preparation method of 5-aminolevulinic acid hydrochloride

-

Paragraph 0038; 0051; 0059-0060, (2021/11/03)

The invention discloses a preparation me...

Preparation method of 5-aminolevulinic acid hydrochloride

-

Paragraph 0043; 0049-0050, (2021/11/06)

The invention discloses a preparation me...

5451-09-2 Process route

5-phthalimidyl levulinic acid
92632-81-0

5-phthalimidyl levulinic acid

5-aminolevulinic acid hydrochloride
5451-09-2

5-aminolevulinic acid hydrochloride

Conditions
Conditions Yield
5-phthalimidyl levulinic acid
92632-81-0

5-phthalimidyl levulinic acid

5-aminolevulinic acid hydrochloride
5451-09-2

5-aminolevulinic acid hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 6h; Reflux;
96.6%
With hydrogenchloride; In water; for 10h; Reflux;
85%
With hydrogenchloride; In water; for 16h; Reflux;
83%
With hydrogenchloride; for 8h; Heating;
63.8%

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