CasNo： 87-52-5
Molecular Formula： C11H14N2
Appearance： beige powder
|
Purification Methods |
Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.] |
|
General Description |
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
InChI:InChI=1/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3
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Indole-3-carboxaldehyde
dimethyl amine
indole-3-carbinol
3-(Dimethylaminomethyl)indole
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate; water;
In
methanol;
at 55 - 60 ℃;
for 2.5h;
|
25% 74% |
indole
formaldehyd
dimethyl amine
3-(Dimethylaminomethyl)indole
| Conditions | Yield |
|---|---|
|
With
zinc(II) chloride;
In
ethanol;
at 20 ℃;
for 1.5h;
|
98% |
|
With
acetic acid;
In
water;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
|
98% |
|
In
water;
at 160 - 170 ℃;
for 0.02h;
under 5250.4 Torr;
Irradiation;
|
97% |
|
With
acetic acid;
In
1,4-dioxane; water;
at 0 - 20 ℃;
for 20h;
|
90% |
|
In
1,4-dioxane; water; acetic acid;
at 0 - 20 ℃;
for 20h;
|
90% |
|
|
88% |
|
formaldehyd; dimethyl amine;
at 75 ℃;
Neat (no solvent);
indole;
at 75 ℃;
Neat (no solvent);
|
80% |
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.166667h;
indole;
In
tetrahydrofuran; water;
at 20 ℃;
|
70% |
|
With
acetic acid;
In
water;
at 0 - 20 ℃;
for 16h;
|
66% |
|
indole; formaldehyd; dimethyl amine;
With
acetic acid;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
Inert atmosphere;
With
sodium hydroxide;
In
tetrahydrofuran; water;
|
30% |
|
With
acetic acid;
at 20 ℃;
|
|
|
Acidic conditions;
|
|
|
With
acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 - 20 ℃;
|
|
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
indole;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 - 20 ℃;
Schlenk technique;
Inert atmosphere;
|
|
|
formaldehyd;
With
acetic acid;
In
1,4-dioxane; water;
at 0 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
indole; dimethyl amine;
In
1,4-dioxane; water;
at 0 ℃;
for 2h;
|
|
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
1,4-dioxane; water;
at 0 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
indole;
In
1,4-dioxane; water;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
Schlenk technique;
|
indole
bis-(dimethylamino)methane
N,N-dimethyl(methylene)ammonium chloride
formaldehyd
3,3'-diindolylmethane
α-N-methyltryptophan
N-[(1H-indol-3-yl)methyl]benzenesulfonamide
ethyl 3-(1H-indol-3-yl)-2-nitropropanoate
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