CasNo: 147-24-0
Molecular Formula: C17H21NO.HCl
Appearance: White crystalline powder
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Diphenhydramine is a H1-histamine receptor antagonist with anticholinergic (drying) and sedative side effects. It is categorized as an antihistaminic; sedative, hypnotic, treatment of allergic. It is used to treat allergy and cold symptoms such as sneezing, runny nose, watery eyes, urticaria (hives), skin rash, and pruritus (itchy skin).
2-diphenylmethoxy-N,N-dimethylethanamine
diphenhydramine hydrochloride
Conditions | Yield |
---|---|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 1h;
Time;
|
9.6 mmol |
2-(N,N-dimethylamino)ethanol
Bromodiphenylmethane
diphenhydramine hydrochloride
Conditions | Yield |
---|---|
2-(N,N-dimethylamino)ethanol; Bromodiphenylmethane;
In
toluene;
for 20h;
Reflux;
With
hydrogenchloride;
In
diethyl ether;
at 25 ℃;
|
The CAS number of Diphenhydramine hydrochloride is 147-24-0.
More information of Diphenhydramine hydrochloride 147-24-0 are:
CAS Number |
147-24-0 |
Density |
1.024 g/cm3 |
Melting Point |
168-172 °C |
Boiling Point |
343.7 °C at 760 mmHg |
Flash Point |
101.5 °C |
Refractive Index |
1.5800 (estimate) |
HS CODE |
29221990 |
PSA |
12.47000 |
LogP |
4.15620 |
Synonyms for Diphenhydramine hydrochloride 147-24-0:Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (9CI);2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride;Alledryl;Allergina;Amidryl;Bagodryl;Bena;Benadrilhydrochloride;Benison;Benodine;Benzantin;Benzhydrol b-dimethylaminoethyl ether hydrochloride;Denydryl;Dibondrin;Dimedrol;Diphantine;Fenylhist;
The chemical formula of Diphenhydramine hydrochloride is C17H21NO.HCl which containing 17 Carbon atoms,22 Hydrogen atoms,1 Nitrogen atoms and 1 Chlorine atoms,and the molecular weight of Diphenhydramine hydrochloride is 291.821.
Diphenhydramine is most commonly used as a first-generation antihistamine and is globally marketed in various brand formulations (Benadryl?, Unisom?, Tylenol?, Zzzquil?). It competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Diphenhydramine exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities.
InChI:InChI=1/C17H21NO.2ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;;/h3-12,17H,13-14H2,1-2H3;2*1H
Relevant articles related to Diphenhydramine hydrochloride:
Article |
Source |
End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts |
Snead, David R.,Jamison, Timothy F. , p. 2822 - 2827 (2013) |
Method for preparing toluene benzyl phenyl substituted compound |
- Paragraph 0028; 0029; 0030; 0031, (2018/03/26) |
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