Agrochemicals

36082-50-5

  • Product Name：5-Bromo-2,4-dichloropyrimidine
  • Molecular Formula：C4HBrCl2N2
  • Specifications：99%
  • Molecular Weight：227.875
Inquiry

Product Details;

CasNo： 36082-50-5

Molecular Formula： C4HBrCl2N2

Appearance： light yellow solid or liquid

Offer Chemical Raw Material 5-Bromo-2,4-dichloropyrimidine 36082-50-5 In Stock

  • Molecular Formula:C4HBrCl2N2
  • Molecular Weight:227.875
  • Appearance/Colour:light yellow solid or liquid 
  • Vapor Pressure:0.004mmHg at 25°C 
  • Melting Point:29-30 °C(lit.) 
  • Refractive Index:n20/D 1.603(lit.)  
  • Boiling Point:287.476 °C at 760 mmHg 
  • PKA:-4.26±0.29(Predicted) 
  • Flash Point:127.661 °C 
  • PSA：25.78000 
  • Density:1.965 g/cm3 
  • LogP:2.54590 

Hebei Jinshengzhongtai Co., Ltd specializes in processing and selling chemical raw materials. It has more than 10 years of production experience. The Jinshengzhongtai range of products includes pharmaceutical intermediates, dye intermediates,detergent raw material, cosmetics raw materials and chemical reagents. Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country. Our high quality products and service have lead us won a set of clients through out the world such as South America, Southeast, Asia, Africa, Middle East and European countries. From beginning to end, we uphold our enterprise spirit of "Quality first sincerity foremost". We warmly welcome all foreign friends to be our business partners on the basis of mutual benefits, and wish to establish good relationship with each other in the near future.

5-Bromo-2,4-dichloropyrimidine(Cas 36082-50-5) Usage

General Description

5-Bromo-2,4-dichloropyrimidine is a halogenoprimidine. It has been reported as an intermediate during the synthesis of 2,4-di-t-butoxy-5-bromopyrimidine and 2,4-di-t-butoxy-5-pyrimidineboronic acid.
Uses 5-Bromo-2,4-dichloropyrimidine is a halogenated pyrimidine compound, a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly for drug discovery and crop protection.

InChI:InChI=1/C4HBrCl2N2/c5-2-1-8-4(7)9-3(2)6/h1H

36082-50-5 Relevant articles

The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist

Moir, Michael,Lane, Samuel,Montgomery, Andrew P.,Hibbs, David,Connor, Mark,Kassiou, Michael

, (2020/12/21)

The development of selective CB2 recepto...

Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis

Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua

supporting information, p. 146 - 153 (2020/03/10)

The chlorination of hydroxy aza-arenes w...

Preparation method for 2,4-dichloropyrimidine and derivatives thereof

-

Paragraph 0046; 0047, (2019/04/14)

The invention discloses a preparation me...

Preparation method of chloro-substituted polyhydroxy aza-aromatic ring compound (by machine translation)

-

Paragraph 0019; 0020; 0021-0024, (2019/10/01)

The invention discloses a preparation me...

36082-50-5 Process route

5-bromouracil
51-20-7

5-bromouracil

2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

Conditions
Conditions Yield
With phosphorus pentachloride; In 1,1,2-trichloroethane; Reagent/catalyst; Solvent; Reflux;
99.5%
With N,N-dimethyl-aniline; trichlorophosphate; at 120 - 130 ℃; for 1.33333h;
96.6%
With phosgene; Tributylphosphine oxide; at -5 - 125 ℃; for 1.83333h; Inert atmosphere;
89.7%
With trichlorophosphate; at 125 ℃; for 120h;
87%
With trichlorophosphate;
82%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 10 ℃; for 16h; Inert atmosphere;
81%
With trichlorophosphate; at 125 ℃;
 
With N,N-diethylaniline; trichlorophosphate;
 
With phosphorus pentachloride; trichlorophosphate; Heating;
 
With N,N-diethylaniline; trichlorophosphate; for 5h; Heating / reflux;
 
With magnesium sulfate; 2,3-Dimethylaniline; trichlorophosphate;
 
With N,N-dimethyl-aniline; trichlorophosphate; at 120 ℃; for 2h;
 
With trichlorophosphate; for 4h;
 
With N,N-dimethyl-aniline; trichlorophosphate; Reflux;
 
With trichlorophosphate;
 
2,4-dihydroxy-5-bromopyrimidine
51-20-7

2,4-dihydroxy-5-bromopyrimidine

2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

Conditions
Conditions Yield
With pyridine; trichlorophosphate; at 160 ℃; for 2h; Autoclave; neat (no solvent);
91%
With dmap; thionyl chloride; bis(trichloromethyl) carbonate; for 12.5h; Reflux; Green chemistry;
90%
With phosphorus pentachloride; trichlorophosphate;
 

36082-50-5 Upstream products

  • 51-20-7
    51-20-7

    5-bromouracil

  • 51-20-7
    51-20-7

    2,4-dihydroxy-5-bromopyrimidine

  • 10026-13-8
    10026-13-8

    phosphorus pentachloride

  • 10025-87-3
    10025-87-3

    trichlorophosphate

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