Catalyst and Auxiliary

140-66-9

  • Product Name：4-tert-Octylphenol
  • Molecular Formula：C14H22O
  • Specifications：99%
  • Molecular Weight：206.328
Inquiry

Product Details;

CasNo： 140-66-9

Molecular Formula： C14H22O

Appearance： white powder

Top quality factory supply 140-66-9 4-tert-Octylphenol at low price

  • Molecular Formula:C14H22O
  • Molecular Weight:206.328
  • Appearance/Colour:white powder 
  • Vapor Pressure:0.00025mmHg at 25°C 
  • Melting Point:79-82 °C(lit.) 
  • Refractive Index:1.507 
  • Boiling Point:282.3 °C at 760 mmHg 
  • PKA:10.15±0.15(Predicted) 
  • Flash Point:148.3 °C 
  • PSA：20.23000 
  • Density:0.935 g/cm3 
  • LogP:4.10600 

Hebei Jinshengzhongtai Co., Ltd specializes in processing and selling chemical raw materials. It has more than 10 years of production experience. The Jinshengzhongtai range of products includes pharmaceutical intermediates, dye intermediates,detergent raw material, cosmetics raw materials and chemical reagents. Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country. Our high quality products and service have lead us won a set of clients through out the world such as South America, Southeast, Asia, Africa, Middle East and European countries. From beginning to end, we uphold our enterprise spirit of "Quality first sincerity foremost". We warmly welcome all foreign friends to be our business partners on the basis of mutual benefits, and wish to establish good relationship with each other in the near future.

4-tert-Octylphenol(Cas 140-66-9) Usage

General Description

4-tert-Octylphenol is a potential environmental pollutant and it exhibits toxic and estrogenic effects on mammalian cells. It binds to estrogen receptors and exerts estrogenic actions in vitro. The transformation of the 4-tert-octylphenol upon irradiation at 253.7nm and by hydroxyl radicals generated by the photolysis (λexc = 253.7nm) of hydrogen peroxide in aqueous solution has been studied.

Health effects

4-tert-octylphenol (OP) is an endocrine-disrupting chemical that causes harmful effects to human health.a common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy.

Environmental Fate

Studies have shown that 4t-OP will adsorb to sediments.

Purification Methods

Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.]

Toxicity evaluation

4t-OP has been shown to be an estrogen receptor (ER) agonist. Estrogenic effects of 4t-OP have been demonstrated in human cells, with 4t-OP displacing the natural estrogen 17b estradiol from its receptor, and 4t-OP inducing cell proliferation in estrogen-dependent cell proliferation assays. In vivo confirmation of 4t-OP’s estrogenicity has been confirmed with the uterotrophic assay.

InChI:InChI=1/C14H22O/c1-2-3-4-5-6-7-8-13-9-11-14(15)12-10-13/h9-12,15H,2-8H2,1H3

140-66-9 Relevant articles

-

Simons,Archer

, p. 451 (1940)

-

Alkylation of Phenol with tert-Butanol in a Draining-Film Reactor

Maksimov, A. L.,Mel’chakov, I. S.,Terekhov, A. V.,Zanaveskin, L. N.

, p. 569 - 575 (2021/07/26)

The alkylation of phenol with tert-butan...

Chloroindate(iii) ionic liquids as catalysts for alkylation of phenols and catechol with alkenes

Gunaratne, H. Q. Nimal,Lotz, Tobias J.,Seddon, Kenneth R.

scheme or table, p. 1821 - 1824 (2011/01/07)

Chloroindate(iii) ionic liquids are show...

Synthesis of 4-tert-octylphenol and 4-cumylphenol by metal triflate and metal triflimidate catalysts

Le Rouzo, Guillaume,Morel-Grepet, Marielle,Simonato, Jean-Pierre

, p. 521 - 522 (2007/10/03)

Metal inflates and metal triflimidates a...

140-66-9 Process route

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

phenol
108-95-2,27073-41-2

phenol

para-tert-butylphenol
98-54-4

para-tert-butylphenol

2-tert-Butylphenol
88-18-6

2-tert-Butylphenol

2,4-di-tert-Butylphenol
96-76-4

2,4-di-tert-Butylphenol

tert-octylphenol
140-66-9

tert-octylphenol

isobutene
115-11-7,15220-85-6

isobutene

Conditions
Conditions Yield
With beta zeolite; at 90 ℃; Temperature;
 
4-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxycarbonylmethyl]-benzoic acid

4-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxycarbonylmethyl]-benzoic acid

4-(carboxymethyl)benzoic acid
501-89-3

4-(carboxymethyl)benzoic acid

tert-octylphenol
140-66-9

tert-octylphenol

Conditions
Conditions Yield
With phosphate buffer; In acetonitrile; at 21 ℃; Rate constant; other buffer; different pH; also in the presence of amidine or molecularly imprinted polymers as catalysts;
 

140-66-9 Upstream products

  • 872823-89-7
    872823-89-7

    phenyl-(1,1,3,3-tetramethyl-butyl)-ether

  • 42265-56-5
    42265-56-5

    4,4-di-tert-octylphenylamine

  • 107-39-1
    107-39-1

    2,4,4-trimethyl-1-pentene

  • 108-95-2
    108-95-2

    phenol

140-66-9 Downstream products

  • 2315-67-5
    2315-67-5

    2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol

  • 5414-83-5
    5414-83-5

    2-(piperidin-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol

  • 25543-98-0
    25543-98-0

    2-Morpholinomethyl-4-(1,1,3,3-tetramethyl-butyl)-phenol

  • 5454-15-9
    5454-15-9

    1-acetoxy-4-(1,1,3,3-tetramethyl-butyl)-benzene

Relevant Products